The researchers claim to have discovered a novel approach to baldness and hair growth.
Human hair follicles stiffen as people get older, according to their study, which was first published in the journal PNAS. This makes it harder for hair to grow. The process is similar to how stiff joints can become as people get older, making it harder to move around.
Be that as it may, the specialists say, it very well may be an alternate story assuming the hair follicles are relaxed, making it more probable they will deliver hair.
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Enter your email address Your privacy is important to us. Details from the baldness cure study The researchers claim to have discovered a method for growing hair in mice by increasing the production of a tiny RNA called miR-205, which softens the stem cells and makes them less rigid.
The scientists claimed that hair growth in both young and old mice was the result of genetically manipulating the stem cells to produce more miR-205.
"They began to develop hair in 10 days," Rui Yi, PhD, a teacher of pathology and dermatology at Northwestern's Feinberg Institute of Medication in Illinois and a senior creator of the review, told SciTechDaily.
Yi stated, "These are not new stem cells being produced." The existing stem cells are being stimulated to produce hair. We still frequently have stem cells, but they might not be able to produce hair.
The scientists have demonstrated that it is possible to regulate cell mechanics to stimulate hair growth, according to Yi.
He stated, "Next, we will test whether topically delivered miR-205 can stimulate hair growth first in mice" due to the possibility of delivering microRNA through nanoparticles directly into the skin. We will design experiments to determine, if successful, whether this microRNA can potentially promote human hair growth.
Using advanced microscopy techniques like atomic force microscopy to measure stiffness and two-photon microscopy to observe cell behaviors in live animals, the team carried out the research on genetically engineered mouse models.
According to Dr. Ken Williams Jr., founder of Orange County Hair Restoration in Irvine, California, a surgeon, the study was "nicely designed" with a "hopeful translation to humans," he told Medical News Today.
Williams stated, "The difficulty is that the mouse model does not always translate into the same human observations." I don't want to get too excited about these results. Deciding the viability or advantage from these studies is too soon. We are hopeful that human applications will benefit from additional research.
Other methods for growing hair Williams also mentioned that a number of medications are currently in the clinical trial phase and may also be beneficial to humans.
“DHT inhibitors such as finasteride and induction medications such as minoxidil, which stimulate hair growth, are currently the proven medical therapies. He added, "Low laser light therapy (LLLT) and platelet rich plasma (PRP) are two other well-known regenerative therapies that have been demonstrated to be safe, tolerable, and effective."
Williams stated that other approaches, such as hair cloning, appeared promising in studies on mice but failed to translate to humans.
Williams told medical News Today, "Hair cloning has been tried for over one and a half decades with good results in the mouse model but disappointing results in humans."
What factors influence hair growth?
Dr. Alan Bauman is a surgeon who specializes in hair restoration and is the
founder, medical director, and chief medical officer of the Florida-based
Bauman
Medical Hair Transplant & Hair Loss Treatment Center.
Medical News Today was informed by Bauman that the success of various treatments for hair loss is contingent on the specific DNA of each patient.
According to Bauman's explanation, "Age is a factor, but there are countless other factors that play into it, including hormones and whether a patient is predisposed to male or female pattern baldness." Those factors may be even more important than age to a hair follicle that does not produce hair.
Culture.org's chief scientist is Grace Angelique Magalit, who holds a PhD in molecular biology and biotechnology. She told Medical News Today that a new medication for hair loss could be one of the most sought-after ever.
Magalit stated, "Baldness is hereditary, so many people experience it." Since being bald has also been associated with low self-esteem, a drug that can help with this will be extremely popular.
According to Magalit, there is a good chance that the method will work on humans.
She stated, "However, years of human clinical trials will be conducted prior to its release to the market." This could potentially have some undesirable effects in humans that are not seen in mice due to the differences in chromosome numbers and bodily functions between humans and mice. Consequently, clinical trials are required.
Medical News Today was informed by Bauman that the success of various treatments for hair loss is contingent on the specific DNA of each patient.
According to Bauman's explanation, "Age is a factor, but there are countless other factors that play into it, including hormones and whether a patient is predisposed to male or female pattern baldness." Those factors may be even more important than age to a hair follicle that does not produce hair.
Culture.org's chief scientist is Grace Angelique Magalit, who holds a PhD in molecular biology and biotechnology. She told Medical News Today that a new medication for hair loss could be one of the most sought-after ever.
Magalit stated, "Baldness is hereditary, so many people experience it." Since being bald has also been associated with low self-esteem, a drug that can help with this will be extremely popular.
According to Magalit, there is a good chance that the method will work on humans.
She stated, "However, years of human clinical trials will be conducted prior to its release to the market." This could potentially have some undesirable effects in humans that are not seen in mice due to the differences in chromosome numbers and bodily functions between humans and mice. Consequently, clinical trials are required.
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